Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2004 Apr;31(4):495-500.

[Screening of DNA topoisomerase inhibitors]

[Article in Japanese]
Toshiwo Andoh  1 , Ken Umemura, Kae Yanase, Noriko Takahashi
Affiliations
  • PMID: 15114689

[Screening of DNA topoisomerase inhibitors]

[Article in Japanese]
Toshiwo Andoh et al. Gan To Kagaku Ryoho. 2004 Apr.

Abstract

It has been established that etoposide (ETP), adriamycin (doxorubicin: DOX) and irinotecan (CPT-11), efficacious antitumor drugs widely used in clinics, target DNA topoisomerases (topo) in vivo. The present report attempts to explain why topos are the good targets of anticancer drugs from the point of view of enzymology of the enzymes and cell cycle behavior of tumor cells. Thus, many candidate anticancer drugs targeting topos are being screened, and preclinical and clinical studies thereof are being conducted world-wide and in Japan.

PubMed Disclaimer

LinkOut - more resources