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. 2004 Jun 18;304(5678):1815-9.
doi: 10.1126/science.1097468. Epub 2004 Apr 29.

Vesicular glutamate transporters 1 and 2 target to functionally distinct synaptic release sites

Robert T Fremeau Jr  1 , Kaiwen Kam, Tayyaba Qureshi, Juliette Johnson, David R Copenhagen, Jon Storm-Mathisen, Farrukh A Chaudhry, Roger A Nicoll, Robert H Edwards
Affiliations

Vesicular glutamate transporters 1 and 2 target to functionally distinct synaptic release sites

Robert T Fremeau Jr et al. Science. .

Abstract

Vesicular glutamate transporters (VGLUTs) 1 and 2 show a mutually exclusive distribution in the adult brain that suggests specialization for synapses with different properties of release. Consistent with this distribution, inactivation of the VGLUT1 gene silenced a subset of excitatory neurons in the adult. However, the same cell populations exhibited VGLUT1-independent transmission early in life. Developing hippocampal neurons transiently coexpressed VGLUT2 and VGLUT1 at distinct synaptic sites with different short-term plasticity. The loss of VGLUT1 also reduced the reserve pool of synaptic vesicles. Thus, VGLUT1 plays an unanticipated role in membrane trafficking at the nerve terminal.

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