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Review
. 2004 Jun;70(6):539-52.
doi: 10.1016/j.plefa.2003.12.001.

From bench to the clinic: gamma-linolenic acid therapy of human gliomas

Undurti N Das  1
Affiliations
Review

From bench to the clinic: gamma-linolenic acid therapy of human gliomas

Undurti N Das. Prostaglandins Leukot Essent Fatty Acids. 2004 Jun.

Abstract

Malignant gliomas are among the most devastating of cancers and are a major cause of mortality in a young population with a median survival time of 9 months following cytoreductive surgery, radiotherapy and chemotherapy. Recent studies showed that polyunsaturated fatty acids especially gamma-linolenic acid (GLA) have selective tumoricidal action especially against malignant glioma cells both in vitro and in vivo. Limited open label clinical studies showed that intratumoral injection/infusion of GLA is safe and effective against malignant gliomas. In view of this, large-scale, double blind studies are needed to establish the usefulness of GLA in the treatment of malignant brain tumors.

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