Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2004 Jun;28(6):547-50.
doi: 10.1016/j.leukres.2003.09.016.

FLT3 mutation and response to intensive chemotherapy in young adult and elderly patients with normal karyotype

Miloslav Beran  1 , Rajyalakshmi Luthra, Hagop Kantarjian, Elihu Estey
Affiliations

FLT3 mutation and response to intensive chemotherapy in young adult and elderly patients with normal karyotype

Miloslav Beran et al. Leuk Res. 2004 Jun.

Abstract

The prognostic impact of FLT3 mutations on the outcome of patients with diploid AML, treated with intensive chemotherapy, was analyzed. In 176 patients, the frequency of single ITD was 30% (<61 years: 37%, >60 years: 23%), single D835 mutation 2.3%, and both 2.3%. There was no association between ITD and CR rate. ITD-positive patients <61 years had a higher frequency of resistant disease. ITD was adversely associated with CR duration and survival in both younger and elderly patients treated with comparable chemotherapy but the effect was less in the elderly. Presence of both ITD and D835 heralded the least favorable outcome.

PubMed Disclaimer

MeSH terms

Substances

LinkOut - more resources