Case Reports
doi: 10.1016/S0140-6736(04)16104-7.
Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells
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- PMID: 15121408
- DOI: 10.1016/S0140-6736(04)16104-7
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Case Reports
Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells
Lancet.
.
Abstract
Adult bone-marrow-derived mesenchymal stem cells are immunosuppressive and prolong the rejection of mismatched skin grafts in animals. We transplanted haploidentical mesenchymal stem cells in a patient with severe treatment-resistant grade IV acute graft-versus-host disease of the gut and liver. Clinical response was striking. The patient is now well after 1 year. We postulate that mesenchymal stem cells have a potent immunosuppressive effect in vivo.
Comment in
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Immunomodulatory functions of mesenchymal stem cells.Lancet. 2004 May 1;363(9419):1411-2. doi: 10.1016/S0140-6736(04)16134-5. Lancet. 2004. PMID: 15121399 No abstract available.
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Mesenchymal stem cells for acute graft-versus-host disease.Lancet. 2008 Aug 30;372(9640):715-6; author reply 716. doi: 10.1016/S0140-6736(08)61299-4. Lancet. 2008. PMID: 18761216 No abstract available.
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