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. 2004 Jul 1;23(30):5227-41.
doi: 10.1038/sj.onc.1207643.

Raf promotes human herpesvirus-8 (HHV-8/KSHV) infection

Shaw M Akula  1 , Patrick W Ford, Audy G Whitman, Khalief E Hamden, John G Shelton, James A McCubrey
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Raf promotes human herpesvirus-8 (HHV-8/KSHV) infection

Shaw M Akula et al. Oncogene. .

Abstract

Human herpesvirus-8 (HHV-8/KSHV) is etiologically associated with Kaposi's sarcoma (KS) and other tumors. Constitutive activation of the mitogen-activated protein kinase (MAPK) signaling pathway has been associated with a variety of tumors, including AIDS-related KS. The oncoprotein Raf is situated at a pivotal position in regulating the MAPK pathway. Hence, we analysed the effect of oncoprotein Raf on HHV-8 infectious entry into target cells. Here we report Raf expression to significantly enhance HHV-8 infection of target cells. These findings implicate a role for Raf not only in the infectious entry of HHV-8 but also in modulating KS pathogenesis.

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