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Comment
. 2004 Feb;11(2):151-3.
doi: 10.1016/j.chembiol.2004.02.005.

Finding Cinderella after the ball: a three-hybrid approach to drug target identification

Scott Lefurgy  1 , Virginia Cornish
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Comment

Finding Cinderella after the ball: a three-hybrid approach to drug target identification

Scott Lefurgy et al. Chem Biol. 2004 Feb.

Abstract

A major bottleneck in drug discovery is identifying the targets of small molecules. The yeast three-hybrid assay extends the two-hybrid approach to screen for protein-small molecule interactions. In this issue of Chemistry & Biology, GPC Biotech reports the first application of this promising assay.

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