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. 2004 May 12;126(18):5680-1.
doi: 10.1021/ja049474e.

Copper-catalyzed electrophilic amination of diorganozinc reagents

Ashley M Berman  1 , Jeffrey S Johnson
Affiliations

Copper-catalyzed electrophilic amination of diorganozinc reagents

Ashley M Berman et al. J Am Chem Soc. .

Abstract

The copper-catalyzed electrophilic amination of diorganozinc reagents employing O-acyl N,N-dialkyl hydroxylamine derivatives as aminating agents is described. This reaction offers a general method for the preparation of tertiary amines in high yields and is noteworthy for its convenience both in terms of reaction conditions employed (room temperature, </=1 h) and ease of product isolation (acid/base extractive workup).

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