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. 1992 Jul;138(7):1535-41.
doi: 10.1099/00221287-138-7-1535.

Lack of correlation between colony morphology and lipooligosaccharide content in the Mycobacterium tuberculosis complex

A Lemassu  1 , V V Lévy-Frébault, M A Lanéelle, M Daffé
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Lack of correlation between colony morphology and lipooligosaccharide content in the Mycobacterium tuberculosis complex

A Lemassu et al. J Gen Microbiol. 1992 Jul.

Abstract

Rough and smooth colony variants of the Mycobacterium tuberculosis complex were compared with respect to their composition in trehalose-containing glycolipid antigens in view of the results of a recent investigation suggesting that the chemical basis of rough and smooth colony morphology in mycobacteria may reside in the occurrence of lipooligosaccharides. A careful chemical characterization of the individual glycolipids of the selected strains allowed the identification of the major glycolipids. The comparative study of the glycolipid content of the smooth Canetti strain, its spontaneous rough variant, and 16 additional strains of M. tuberculosis, M. bovis and M. africanum showed that the presence of lipooligosaccharides was not related to the morphology of the colonies.

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