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. 2004 Jun 7;14(11):2729-33.
doi: 10.1016/j.bmcl.2004.03.077.

Tetrahydroisoquinolines as subtype selective estrogen agonists/antagonists

Richard Chesworth  1 , Michael P Zawistoski, Bruce A Lefker, Kimberly O Cameron, Robert F Day, F Michael Mangano, Robert L Rosati, Stacy Colella, Donna N Petersen, Amy Brault, Bihong Lu, Lydia C Pan, Pia Perry, Oicheng Ng, Tessa A Castleberry, Thomas A Owen, Thomas A Brown, David D Thompson, Paul DaSilva-Jardine
Affiliations

Tetrahydroisoquinolines as subtype selective estrogen agonists/antagonists

Richard Chesworth et al. Bioorg Med Chem Lett. .

Abstract

Two series of 6-hydroxy and 7-hydroxy tetrahydroisoquinolines were prepared. Evaluating a range of C-1, C-4, and N-substituents led to the discovery of ER alpha and ER beta selective analogs.

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