[Current progress of matrix metalloproteinase in acute lung injury following cardiopulmonary bypass]

Abstract

Degradation of basement membrane of pulmonary capillaries was the main pathological feature of lung injury following cardiopulmonary bypass (CPB). Matrix metalloproteinases (MMPs) contributed to the development of lung injury following CPB via degrading extracellular matrix and regulating cytokines. So, understanding the effects of MMPs in the lung injury following CPB may be helpful to prevent and treat the complications mentioned above.