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Review
. 2004 Jun;16(3):185-96.
doi: 10.1016/j.smim.2004.02.006.

Role of T cell costimulation in anti-viral immunity

Affiliations
Review

Role of T cell costimulation in anti-viral immunity

Edward M Bertram et al. Semin Immunol. 2004 Jun.

Abstract

Members of both the CD28 and TNFR families can have costimulatory roles in T cell activation. Gene targeted mice as well as in vivo blocking experiments have established distinct roles for CD28/B7; ICOS/ICOSL; CD27/CD70; 4-1BB/4-1BBL and OX40/OX40L during viral infection. Many issues remain to be addressed, including the timing and location of the interactions, the possibility of partial redundancy between related family members and the molecular basis for the specific phenotypes observed in the different gene targeted mice.

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