doi: 10.1016/j.tcb.2004.03.007.
Guardian at the gate: preventing unspliced pre-mRNA export
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- PMID: 15130577
- DOI: 10.1016/j.tcb.2004.03.007
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Guardian at the gate: preventing unspliced pre-mRNA export
Trends Cell Biol.
2004 May.
Abstract
The production of a mature mRNA requires the assembly and cooperation of numerous complexes before nuclear export. The deleterious effects of intron-containing pre-mRNA leakage into the cytoplasm necessitate mechanisms to prevent premature export of partially processed or unprocessed messages. A new study demonstrates that the Saccharomyces cerevisiae protein Mlp1 specifically retains intron-containing pre-mRNAs in the nucleus.
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