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. 2004 May;14(5):222-5.
doi: 10.1016/j.tcb.2004.03.007.

Guardian at the gate: preventing unspliced pre-mRNA export

Jason M Casolari  1 , Pamela A Silver
Affiliations

Guardian at the gate: preventing unspliced pre-mRNA export

Jason M Casolari et al. Trends Cell Biol. 2004 May.

Abstract

The production of a mature mRNA requires the assembly and cooperation of numerous complexes before nuclear export. The deleterious effects of intron-containing pre-mRNA leakage into the cytoplasm necessitate mechanisms to prevent premature export of partially processed or unprocessed messages. A new study demonstrates that the Saccharomyces cerevisiae protein Mlp1 specifically retains intron-containing pre-mRNAs in the nucleus.

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