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Comparative Study
. 2004 May;42(5):2161-7.
doi: 10.1128/JCM.42.5.2161-2167.2004.

Hyperinvasive neonatal group B streptococcus has arisen from a bovine ancestor

Naiel Bisharat  1 , Derrick W Crook, James Leigh, Rosalind M Harding, Phil N Ward, Tracey J Coffey, Martin C Maiden, Tim Peto, Nicola Jones
Affiliations
Comparative Study

Hyperinvasive neonatal group B streptococcus has arisen from a bovine ancestor

Naiel Bisharat et al. J Clin Microbiol. 2004 May.

Abstract

The genetic relatedness and evolutionary relationships between group B streptococcus (GBS) isolates from humans and those from bovines were investigated by phylogenetic analysis of multilocus sequence typing data. The collection of isolates consisted of 111 GBS isolates from cows with mastitis and a diverse global collection of GBS isolates from patients with invasive disease (n = 83) and carriers (n = 69). Cluster analysis showed that the majority of the bovine isolates (93%) grouped into one phylogenetic cluster. The human isolates showed greater diversity and clustered separately from the bovine population. However, the homogeneous human sequence type 17 (ST-17) complex, known to be significantly associated with invasive neonatal disease, was the only human lineage found to be clustered within the bovine population and was distinct from all the other human lineages. Split decomposition analysis revealed that the human isolate ST-17 complex, the major hyperinvasive neonatal clone, has recently arisen from a bovine lineage.

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Figures

FIG. 1.
FIG. 1.
UPGMA tree showing the genetic relatedness of bovine, human, and other GBS strains. Bootstrap values are the percentages of 500 computer-generated trees produced by randomly sampling the sequences and are shown at the nodes. Values of less than 70 are not shown. Underlined STs indicate those to be pruned for further analysis.
FIG. 2.
FIG. 2.
Split graphs showing the relationship between bovine, human, and other GBS strains. The numbers at the nodes indicate the ST(s). Human STs are shown in blue, bovine STs are shown in red, STs found in humans and bovines are shown in black, and STs from other animals are shown in green. Underlined numbers indicate the STs to be pruned. Split graphs express conflicting phylogenies in the sequence data as net-like topologies.
FIG. 3.
FIG. 3.
Split graphs showing the relationship between bovine and human GBS strains after progressive pruning of the data. The designations A to E at the splits correspond to the letters shown in Fig. 1. The color indicators are is described in the legend to Fig. 2.
See this image and copyright information in PMC

References

    1. American Academy of Pediatrics Committee on Infectious Diseases and Committee on Fetus and Newborn. 1997. Revised guidelines for prevention of early-onset group B streptococcal (GBS) infection. Pediatrics 99:489-497. - PubMed
    1. American College of Obstetricians and Gynecologists Committee on Obstetric Practice. 1996. Prevention of early-onset group B streptococcal disease in newborns. ACOG committee opinion. American College of Obstetricians and Gynecologists, Washington, D.C. - PubMed
    1. Baker, C. J., and M. S. Edwards. 1995. Group B streptococcal infections, p. 980-1054. In J. Remington and J. O. Klein (ed.), Infectious diseases of the fetus and newborn infant. The W. B. Saunders Co., Philadelphia, Pa.
    1. Baseggio, N., P. D. Mansell, J. W. Browning, and G. F. Browning. 1997. Strain differentiation of isolates of streptococci from bovine mastitis by pulsed-field gel electrophoresis. Mol. Cell. Probes 11:349-354. - PubMed
    1. Breed, R. S. (ed.). 1957. Bergey's manual of determinative bacteriology, 7th ed., p. 517-518. The Williams & Wilkins Co., Baltimore, Md.

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