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. 2004 May;42(5):2271-4.
doi: 10.1128/JCM.42.5.2271-2274.2004.

Asymptomatic and symptomatic excretion of noroviruses during a hospital outbreak of gastroenteritis

Chris I Gallimore  1 , David Cubitt, Nelita du Plessis, Jim J Gray
Affiliations

Asymptomatic and symptomatic excretion of noroviruses during a hospital outbreak of gastroenteritis

Chris I Gallimore et al. J Clin Microbiol. 2004 May.

Abstract

During an investigation of a hospital outbreak of norovirus gastroenteritis identified as being caused by a recombinant genogroup II (rGII-3a) strain, fecal specimens collected from asymptomatic staff and patients were tested by nested PCR. A GII-4 norovirus strain, the predominant strain associated with outbreaks in hospitals over the last few years, was detected in 26 and 33% of asymptomatic staff and patients, respectively. No rGII-3a (Harrow/Mexico) norovirus strains were detected in the samples of asymptomatic staff or patients.

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Figures

FIG. 1.
FIG. 1.
Dendrogram of ORF1 nucleotide sequence from NV strains cocirculating in asymptomatic and symptomatic staff and/or patients from an outbreak of gastroenteritis in June to July 2002. GenBank strains are GB-Southampton/1991/UK (L07418), Norwalk/1968/US (M87661), Desert Shield/1990/SA (U04469), Potsdam196/2000/DE (AF312724), Halle445/1999/DE (AF312513), Lordsdale/1995/UK (X86557), Hawaii/1972/US (U07611), Berlin386/2000/DE (AF312524), Snow Mountain (L23831), Melksham/1995/UK (X81879), Bad Berleberg/477/01 (AF40906), and Mexico/1989/MX (U22498. Enteric virus unit strains include Grimsby/1995/UK (18), Valetta/1995/MA (18), Leeds/1990/UK (18) and Harrow/2001/UK (unpublished data). The sequence of strains P and S from this study can be obtained by contacting the corresponding author. NV strains from patients January to May 2002 (P-B, P-D, P-F, P-G, and P-K) are included for comparison (unpublished data); strain P11 was from an asymptomatic patient in February 2002.
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