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. 2004 May 7:2:12.
doi: 10.1186/1477-7819-2-12.

Barrett's oesophagus and adenocarcinoma

Christine P J Caygill  1 , Anthony Watson, Pierre Lao-Sirieix, Rebecca C Fitzgerald
Affiliations

Barrett's oesophagus and adenocarcinoma

Christine P J Caygill et al. World J Surg Oncol. .
No abstract available

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Figures

Figure 1
Figure 1
Overview of the G1/S transition of the cell cycle. Following stimulation of proliferation, accumulation of cyclin D1-CDK4/6 complex will lead to phosphorylation of retinoblastoma protein (pRB) thus allowing E2F to promote expression of genes leading to progression from the G1 phase to the S phase of the cell cycle. Cyclin E-CDK2 allow further phosphorylation of RB creating a positive feedback loop. Intracellular or extracellular factors such as DNA damage or lack of required growth factors can influence this process in a negative fashion (e.g.: through p21 or p53).
See this image and copyright information in PMC

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