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Clinical Trial
. 2004 May;122(5):716-26.
doi: 10.1001/archopht.122.5.716.

Associations of mortality with ocular disorders and an intervention of high-dose antioxidants and zinc in the Age-Related Eye Disease Study: AREDS Report No. 13

Traci E Clemons  1 , Natalie Kurinij, Robert D Sperduto; AREDS Research Group
Affiliations
Clinical Trial

Associations of mortality with ocular disorders and an intervention of high-dose antioxidants and zinc in the Age-Related Eye Disease Study: AREDS Report No. 13

Traci E Clemons et al. Arch Ophthalmol. 2004 May.

Abstract

Objective: To assess the association of ocular disorders and high doses of antioxidants or zinc with mortality in the Age-Related Eye Disease Study (AREDS).

Methods: Baseline fundus and lens photographs were used to grade the macular and lens status of AREDS participants. Participants were randomly assigned to receive oral supplements of high-dose antioxidants, zinc, antioxidants plus zinc, or placebo. Risk of all-cause and cause-specific mortality was assessed using adjusted Cox proportional hazards models.

Results: During median follow-up of 6.5 years, 534 (11%) of 4753 AREDS participants died. In fully adjusted models, participants with advanced age-related macular degeneration (AMD) compared with participants with few, if any, drusen had increased mortality (relative risk [RR], 1.41; 95% confidence interval [CI], 1.08-1.86). Advanced AMD was associated with cardiovascular deaths. Compared with participants having good acuity in both eyes, those with visual acuity worse than 20/40 in 1 eye had increased mortality (RR, 1.36; 95% CI, 1.12-1.65). Nuclear opacity (RR, 1.40; 95% CI, 1.12-1.75) and cataract surgery (RR, 1.55; 95% CI, 1.18-2.05) were associated with increased all-cause mortality and with cancer deaths. Participants randomly assigned to receive zinc had lower mortality than those not taking zinc (RR, 0.73; 95% CI, 0.61-0.89).

Conclusions: The decreased survival of AREDS participants with AMD and cataract suggests that these conditions may reflect systemic rather than only local processes. The improved survival in individuals randomly assigned to receive zinc requires further study.

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Figures

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Covariate-adjusted estimates of the probability of all-cause mortality by age-related macular degeneration (AMD) Category (A), visual acuity (VA) (B), cataract surgery (C), nuclear opacity grade (D), zinc treatment (E), and Age-Related Eye Disease Study treatment (F).
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References

    1. Street DA, Javitt JC. National five-year mortality after inpatient cataract extraction. Am J Ophthalmol. 1992;113:263–268. - PubMed
    1. Benson WH, Farber ME, Caplan RJ. Increased mortality rates after cataract surgery: a statistical analysis. Ophthalmology. 1988;95:1288–1292. - PubMed
    1. Hirsch RP, Schwartz B. Increased mortality among elderly patients undergoing cataract extraction. Arch Ophthalmol. 1983;101:1034–1037. - PubMed
    1. Ninn-Pedersen K, Stenevi U. Cataract patients in a defined Swedish population 1986–90, VII: inpatient and outpatient standardized mortality ratios. Br J Ophthalmol. 1995;79:1115–1119. - PMC - PubMed
    1. Hu FB, Hankinson SE, Stampfer MJ, et al. Prospective study of cataract extraction and risk of coronary heart disease in women. Am J Epidemiol. 2001;153:875–881. - PubMed

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