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Comparative Study
. 2004 May;11(3):625-6.
doi: 10.1128/CDLI.11.3.625-626.2004.

Toll-like receptor 2 Arg677Trp polymorphism is associated with susceptibility to tuberculosis in Tunisian patients

Meriem Ben-Ali  1 , Mohamed-Ridha Barbouche, Soufia Bousnina, Abdellatif Chabbou, Koussay Dellagi
Affiliations
Comparative Study

Toll-like receptor 2 Arg677Trp polymorphism is associated with susceptibility to tuberculosis in Tunisian patients

Meriem Ben-Ali et al. Clin Diagn Lab Immunol. 2004 May.

Abstract

Toll-like receptor 2 (TLR2) is critical in the immune response to mycobacteria. Herein, we report that the frequency of a human TLR2 Arg677Trp polymorphism (C2029T nucleotide substitution) in tuberculosis patients in Tunisia is significantly higher than in healthy controls (P < 0.0001). This finding suggests that this polymorphism could be a risk factor for tuberculosis.

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Figures

FIG. 1.
FIG. 1.
Sequencing results of TLR2 genomic DNA. (A) Heterozygous (wild type/mutation) genotype; (B) homozygous (wild type/wild type) genotype.
See this image and copyright information in PMC

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