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. 2004 Jun;53(6):775-8.
doi: 10.1136/gut.2003.022061.

Clinical implications of E-cadherin associated hereditary diffuse gastric cancer

R C Fitzgerald  1 , C Caldas
Affiliations

Clinical implications of E-cadherin associated hereditary diffuse gastric cancer

R C Fitzgerald et al. Gut. 2004 Jun.

Abstract

Approximately 1-3% of gastric cancers arise as a result of inherited gastric cancer predisposition syndromes. These may be of the diffuse or intestinal type. Linkage analysis has recently implicated E-cadherin mutations in an estimated 25% of families with an autosomal dominant predisposition to diffuse type gastric cancers. This subset of gastric cancer has been termed hereditary diffuse gastric cancer (HDGC).

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