Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2004 May 18;101(20):7493-4.
doi: 10.1073/pnas.0402276101. Epub 2004 May 11.

Turning tRNA upside down: When aminoacylation is not a prerequisite to protein synthesis

Michael Ibba  1 , Christopher Francklyn
Affiliations
Comment

Turning tRNA upside down: When aminoacylation is not a prerequisite to protein synthesis

Michael Ibba et al. Proc Natl Acad Sci U S A. .
No abstract available

PubMed Disclaimer

Figures

Fig. 1.
Fig. 1.
Pathways used by YadB and GluRS to attach glutamate to tRNA. YadB (upper pathway) first activates glutamate (Glu) in the absence of tRNA to yield glutamyl-adenylate (Glu-AMP) and pyrophosphate (PPi). Glu-AMP then serves as substrate for the attachment of glutamate to the Q-base at the first anticodon position of tRNAAsp. In contrast, GluRS (lower pathway) requires the presence of tRNAGlu for Glu-AMP synthesis and subsequently attaches glutamate to the 3′-terminal adenosine of tRNAGlu.
See this image and copyright information in PMC

Comment on

References

    1. Ibba, M., Becker, H. D., Stathopoulos, C., Tumbula, D. L. & Söll, D. (2000) Trends Biochem. Sci. 25, 311-316. - PubMed
    1. Schimmel, P. & Ribas De Pouplana, L. (2000) Trends Biochem. Sci. 25, 207-209. - PubMed
    1. Francklyn, C. (2004) in Aminoacyl-tRNA Synthetases, eds. Ibba, M., Francklyn, C. & Cusack, S. (Landes Bioscience, Georgetown, TX), in press.
    1. Sissler, M., Delorme, C., Bond, J., Ehrlich, S. D., Renault, P. & Francklyn, C. (1999) Proc. Natl. Acad. Sci. USA 96, 8985-8990. - PMC - PubMed
    1. Roy, H., Becker, H. D., Reinbolt, J. & Kern, D. (2003) Proc. Natl. Acad. Sci. USA 100, 9837-9842. - PMC - PubMed

MeSH terms

LinkOut - more resources