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. 2004 May 20;47(11):2833-8.
doi: 10.1021/jm031028z.

1-alkyl-4-acylpiperazines as a new class of imidazole-free histamine H(3) receptor antagonists

Florencio Zaragoza  1 , Henrik Stephensen, Sanne M Knudsen, Lone Pridal, Birgitte S Wulff, Karin Rimvall
Affiliations

1-alkyl-4-acylpiperazines as a new class of imidazole-free histamine H(3) receptor antagonists

Florencio Zaragoza et al. J Med Chem. .

Abstract

With the aim of identifying structurally novel, centrally acting histamine H(3) antagonists, arrays of monoacyldiamines were screened. This led to the discovery of a series of 1-alkyl-4-acylpiperazines which were potent antagonists at the human histamine H(3) receptor. The most potent amides had antagonist potencies in the subnanomolar range.

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