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. 2004 Spring;8(1):73-6.
doi: 10.1089/109065704323016067.

Prevalence of alleles associated with HIV resistance in Russia

Grigory S Ryabov  1 , Elena V Kazennova, Marina R Bobkova, Aleksei F Bobkov
Affiliations

Prevalence of alleles associated with HIV resistance in Russia

Grigory S Ryabov et al. Genet Test. 2004 Spring.

Abstract

Genetic polymorphisms of CCR5, CCR2, and SDF1 genes have been associated with resistance during human immunodeficiency virus type 1 (HIV-1) infection and disease progression. In the present report, we studied the frequency and co-occurrence of CCR5Delta32, CCR5-59029A/G, CCR2-64I, and SDF1-3'A allelic variants among HIV-1-seronegative individuals (n = 171) in Moscow. Observed allelic frequencies were 0.0906 [95% confidence interval (CI), 0.06-0.1212] for CCR5Delta32, 0.4072 (95% CI, 0.3542-0.4602) for CCR5-59029G, 0.1061 (95% CI, 0.0728-0.1394) for CCR2-64I, and 0.2218 (95% CI 0.1715-0.2721) for SDF1-3'A. A significant linkage disequilibrium (p = 0.0034) between CCR2-64I and SDF1-3'A alleles was observed.

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