Comparative Study
[Effects of polyunsaturated fatty acids on Krebs cycle in the rat kidney in chronic phosphorus intoxication]
[Article in
Russian]
- PMID: 1514257
Item in Clipboard
Comparative Study
[Effects of polyunsaturated fatty acids on Krebs cycle in the rat kidney in chronic phosphorus intoxication]
[Article in
Russian]
Vopr Pitan.
1992 Mar-Apr.
Abstract
The investigation of Krebs cycle state in kidney homogenates of August rats subjected to oral intoxication with oil solution of yellow phosphorus in a dose of 0.3 mg/kg, has shown that under conditions of balanced nutrition the activity of NAD-dependent isocitrate dehydrogenase, succinate dehydrogenase and accumulation of the substrate fund of the cycle decreased 3.5-fold as compared to the control. The addition of polyunsaturated fatty acids to the ration produced a positive effect on Krebs cycle state: dehydrogenase activity was not significantly changed, accumulation of Krebs cycle substrate was two-fold lower. However, this ration did not completely abolish the toxic action of yellow phosphorus on Krebs cycle.
Similar articles
-
[State of the Krebs cycle in the kidneys of rats with chronic phosphorus intoxication].Biull Eksp Biol Med. 1991 Aug;112(8):161-2. Biull Eksp Biol Med. 1991. PMID: 1786377 Russian. No abstract available.
-
[Effect of a modified low protein and low fat diet on histologic changes and metabolism in kidneys in an experimental model of polycystic kidney disease].Srp Arh Celok Lek. 2002 Jul-Aug;130(7-8):251-7. Srp Arh Celok Lek. 2002. PMID: 12585002 Serbian.
-
Inhibition of Krebs cycle and activation of glyoxylate cycle in the course of chronological aging of Saccharomyces cerevisiae. Compensatory role of succinate oxidation.Biochimie. 2004 Jan;86(1):39-46. doi: 10.1016/j.biochi.2003.10.019. Biochimie. 2004. PMID: 14987799
-
[ Dynamics of NAD-dependent isocitrate dehydrogenase activity in homogenized rat liver exposed to toxic products of the phosphorus industry].Gig Tr Prof Zabol. 1992;(1):21-3. Gig Tr Prof Zabol. 1992. PMID: 1308864 Russian.
-
Polyunsaturated fatty acids, inflammation and immunity.Eur J Clin Nutr. 2002 Aug;56 Suppl 3:S14-9. doi: 10.1038/sj.ejcn.1601478. Eur J Clin Nutr. 2002. PMID: 12142955 Review.