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. 2004 Apr;27(4):234-6.

[An experimental study of the therapeutic effect of interleukin-2 and interleukin-12 with and without amphotericin B on pulmonary fungal infection]

[Article in Chinese]
Chang-ran Zhang  1 , Ying-chun Tang, K Kawakami, Tian-tuo Zhang, Kou-xing Zhang, Jia-xin Zhu
Affiliations
  • PMID: 15144612

[An experimental study of the therapeutic effect of interleukin-2 and interleukin-12 with and without amphotericin B on pulmonary fungal infection]

[Article in Chinese]
Chang-ran Zhang et al. Zhonghua Jie He He Hu Xi Za Zhi. 2004 Apr.

Abstract

Objective: To study the therapeutic effect of interleukin-2 (IL-2) and interleukin-12 (IL-12) with and without amphotericin B on pulmonary fungal infection of mice.

Methods: A mouse model of pulmonary invasive aspergillus fumigatus (IPA) infection was established and the mice were divided into different groups, treated with IL-2 and IL-12 with and without amphotericin B. The survival number of mice in 15 days and the colony count of lung tissue in the different groups were observed.

Results: IL-2, IL-12 and amphotericin B showed synergistic effect in prolonging the survival of the infected mice and reducing the colony count in the lung tissue.

Conclusion: IL-2 and IL-12 are effective adjuvant therapeutic agents in the immunosuppressed hosts.

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