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. 2004 Jun 1;59(2):348-52.
doi: 10.1016/j.ijrobp.2003.10.011.

Proton therapy for prostate cancer: the initial Loma Linda University experience

Jerry D Slater  1 , Carl J Rossi Jr, Les T Yonemoto, David A Bush, B Rodney Jabola, Richard P Levy, Roger I Grove, William Preston, James M Slater
Affiliations

Proton therapy for prostate cancer: the initial Loma Linda University experience

Jerry D Slater et al. Int J Radiat Oncol Biol Phys. .

Abstract

Purpose: We analyzed results of conformal proton radiation therapy for localized prostate cancer, with emphasis on biochemical freedom from relapse.

Methods and materials: Analyses were performed for 1255 patients treated between October 1991 and December 1997. Outcomes were measured on primarily in terms of biochemical relapse and toxicity.

Results: The overall biochemical disease-free survival rate was 73%, and was 90% in patients with initial PSA <or=4.0; it was 87% in patients with posttreatment PSA nadirs <or=0.50. Rates dropped with rises in initial and nadir PSA values. Long-term survival outcomes were comparable with those reported for other modalities intended for cure.

Conclusions: Conformal proton radiation therapy at the reported dose levels yielded disease-free survival rates comparable with other forms of local therapy, and with minimal morbidity. Dose-escalation strategies are being implemented to further improve long-term results.

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