Comparative Study
doi: 10.1038/nn1250.
Epub 2004 May 16.
Placebo-responsive Parkinson patients show decreased activity in single neurons of subthalamic nucleus
Affiliations
- PMID: 15146189
- DOI: 10.1038/nn1250
Item in Clipboard
Comparative Study
Placebo-responsive Parkinson patients show decreased activity in single neurons of subthalamic nucleus
Nat Neurosci.
2004 Jun.
Abstract
Placebo administration is known to affect the brain both in pain and in Parkinson disease. Here we show that placebo treatment caused reduced activity in single neurons in the subthalamic nucleus of placebo-responsive Parkinsonian patients. These changes in activity were tightly correlated with clinical improvement; no decrease in activity occurred when the clinical placebo response was absent.
Similar articles
-
Rhythm-specific pharmacological modulation of subthalamic activity in Parkinson's disease.Exp Neurol. 2004 Oct;189(2):369-79. doi: 10.1016/j.expneurol.2004.06.001. Exp Neurol. 2004. PMID: 15380487
-
Local field potential beta activity in the subthalamic nucleus of patients with Parkinson's disease is associated with improvements in bradykinesia after dopamine and deep brain stimulation.Exp Neurol. 2008 Sep;213(1):108-13. doi: 10.1016/j.expneurol.2008.05.008. Epub 2008 May 22. Exp Neurol. 2008. PMID: 18619592 Clinical Trial.
-
MK801 and amantadine exert different effects on subthalamic neuronal activity in a rodent model of Parkinson's disease.Exp Neurol. 2005 Jan;191(1):104-18. doi: 10.1016/j.expneurol.2004.08.030. Exp Neurol. 2005. PMID: 15589517
-
Characterization of the thalamic-subthalamic circuit involved in the placebo response through single-neuron recording in Parkinson patients.Cortex. 2014 Nov;60:3-9. doi: 10.1016/j.cortex.2013.12.003. Epub 2013 Dec 24. Cortex. 2014. PMID: 24457096 Review.
-
[Electrophysiology of subthalamic nucleus in normal and Parkinson's disease].Acta Neurol Taiwan. 2006 Sep;15(3):206-16. Acta Neurol Taiwan. 2006. PMID: 16995602 Review. Chinese.
Cited by
-
Opinion: A role for placebo therapy in psychogenic movement disorders.Nat Rev Neurol. 2013 Jun;9(6):351-6. doi: 10.1038/nrneurol.2013.65. Epub 2013 Apr 30. Nat Rev Neurol. 2013. PMID: 23628738 Review.
-
Nonconscious activation of placebo and nocebo pain responses.Proc Natl Acad Sci U S A. 2012 Sep 25;109(39):15959-64. doi: 10.1073/pnas.1202056109. Epub 2012 Sep 10. Proc Natl Acad Sci U S A. 2012. PMID: 23019380 Free PMC article. Clinical Trial.
-
Placebo-related effects in clinical trials in schizophrenia: what is driving this phenomenon and what can be done to minimize it?Int J Neuropsychopharmacol. 2012 Aug;15(7):1003-14. doi: 10.1017/S1461145711001738. Epub 2012 Jan 5. Int J Neuropsychopharmacol. 2012. PMID: 22217384 Free PMC article. Review.
-
Spontaneous sleep modulates the firing pattern of parkinsonian subthalamic nucleus.Exp Brain Res. 2006 Jan;168(1-2):277-80. doi: 10.1007/s00221-005-0175-y. Epub 2005 Nov 18. Exp Brain Res. 2006. PMID: 16328297
-
Advances in gene therapy for movement disorders.Neurotherapeutics. 2008 Apr;5(2):260-9. doi: 10.1016/j.nurt.2008.01.005. Neurotherapeutics. 2008. PMID: 18394568 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
