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Review
. 2004 May 21;14(4):414-6.
doi: 10.1016/s1097-2765(04)00268-0.

Control of DNA synthesis and mitosis by the Skp2-p27-Cdk1/2 axis

Michele Pagano  1
Affiliations
Free article
Review

Control of DNA synthesis and mitosis by the Skp2-p27-Cdk1/2 axis

Michele Pagano. Mol Cell. .
Free article

Abstract

A new study reveals a novel role for p27 in inhibiting Cdk1 activity at G2/M and shows that p27 deficiency almost completely rescues the aberrations observed in Skp2(-/-) mice, demonstrating that p27 is the principal downstream effector of the SCF(Skp2) ubiquitin ligase.

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