Review
doi: 10.1016/s1097-2765(04)00269-2.
Telomeres are double-strand DNA breaks hidden from DNA damage responses
Affiliations
- PMID: 15149591
- DOI: 10.1016/s1097-2765(04)00269-2
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Review
Telomeres are double-strand DNA breaks hidden from DNA damage responses
Mol Cell.
.
Free article
Abstract
A network of ATM/ATR-mediated events regulates cell cycle checkpoints and genomic integrity and contributes to the processing of DNA double-strand breaks in both genomic DNA and at telomeres. In yeast and in human cells, investigators, including, and Herbig et al., published in this issue of Molecular Cell, are beginning to decipher the signaling pathways involved at the telomeres.
Comment on
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Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a).Mol Cell. 2004 May 21;14(4):501-13. doi: 10.1016/s1097-2765(04)00256-4. Mol Cell. 2004. PMID: 15149599
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Reciprocal association of the budding yeast ATM-related proteins Tel1 and Mec1 with telomeres in vivo.Mol Cell. 2004 May 21;14(4):515-22. doi: 10.1016/s1097-2765(04)00262-x. Mol Cell. 2004. PMID: 15149600
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