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. 2004 Jun 21;14(12):3131-4.
doi: 10.1016/j.bmcl.2004.04.046.

Development of an isotope-coded activity-based probe for the quantitative profiling of cysteine proteases

Paul F van Swieten  1 , Rene Maehr, Adrianus M C H van den Nieuwendijk, Benedikt M Kessler, Michael Reich, Chung-Sing Wong, Hubert Kalbacher, Michiel A Leeuwenburgh, Christoph Driessen, Gijsbert A van der Marel, Hidde L Ploegh, Herman S Overkleeft
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Development of an isotope-coded activity-based probe for the quantitative profiling of cysteine proteases

Paul F van Swieten et al. Bioorg Med Chem Lett. .

Abstract

Quantification studies of complex protein mixtures have been restricted mainly to whole cell extracts. Here we describe the synthesis of two sets of isotope-coded activity-based probes that allow quantitative functional proteomics experiments on the cathepsins.

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