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. 2004 Jun 21;14(12):3217-20.
doi: 10.1016/j.bmcl.2004.03.105.

1,7-annulated indolocarbazoles as cyclin-dependent kinase inhibitors

Rima S Al-awar  1 , James E Ray, Kyle A Hecker, Jianping Huang, Philip P Waid, Chuan Shih, Harold B Brooks, Charles D Spencer, Scott A Watkins, Bharvin R Patel, Nancy B Stamm, Catherine A Ogg, Richard M Schultz, Eileen L Considine, Margaret M Faul, Kevin A Sullivan, Stanley P Kolis, John L Grutsch, Sajan Joseph
Affiliations

1,7-annulated indolocarbazoles as cyclin-dependent kinase inhibitors

Rima S Al-awar et al. Bioorg Med Chem Lett. .

Abstract

The synthesis and kinase inhibitory activity of a series of novel 1,7-annulated indolocarbazoles 6 and 16 is described. These compounds exhibited potent inhibitory activity against cyclin-dependent kinase 4 and good antiproliferative activity in a human colon carcinoma cell line.

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