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Review
. 2004 Jun;45(6):683-91.
doi: 10.1016/j.eururo.2004.01.012.

Molecular mechanisms of prostate cancer

Kati P Porkka  1 , Tapio Visakorpi
Affiliations
Review

Molecular mechanisms of prostate cancer

Kati P Porkka et al. Eur Urol. 2004 Jun.

Abstract

During the last ten years our knowledge of genetic alterations in prostate cancer has significantly increased. For example, several chromosomal loci possibly harboring predisposing or somatically mutated genes have been suggested. Still, we lack the comprehensive molecular model for the development and progression of prostate cancer. Only a few genes have been found to be aberrant in a significant proportion of prostate cancer. These include GSTP1, PTEN, TP53, and AR. Thus, they are natural targets for new treatment strategies.

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