Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2004 May 4;90(9):1760-4.
doi: 10.1038/sj.bjc.6601797.

Interaction between cyclooxygenase-2 gene polymorphism and dietary n-6 polyunsaturated fatty acids on colon cancer risk: the Singapore Chinese Health Study

W-P Koh  1 , J-M Yuan, D van den Berg, H-P Lee, M C Yu
Affiliations

Interaction between cyclooxygenase-2 gene polymorphism and dietary n-6 polyunsaturated fatty acids on colon cancer risk: the Singapore Chinese Health Study

W-P Koh et al. Br J Cancer. .

Abstract

This case-control study of 310 colorectal cancer cases and 1177 controls in a nested prospective, population-based cohort of Singapore Chinese subjects found a statistically significant association between the cyclooxygenase (COX)-2 -765G>C gene polymorphism and colon cancer risk among high consumers of dietary n-6 polyunsaturated fatty acids (odds ratio=2.38, 95% confidence interval=1.23-4.59).

PubMed Disclaimer

References

    1. Breslow NE, Day NE (1980) Statistical Methods in Cancer Research: Volume 1 – The Analysis of Case–Control Studies, IARC Scientific Publications No. 32. Lyon: IARC - PubMed
    1. Cao Y, Prescott SM (2002) Many actions of cyclooxygenase-2 in cellular dynamics and in cancer. J Cell Physiol 190: 279–286 - PubMed
    1. Chia KS, Seow A, Lee HP, Shanmugaratnam KS (2000) Cancer Incidence in Singapore, 1993–1997, Singapore Cancer Registry No. 5, Singapore
    1. Coffey RJ, Hawkey CJ, Damstrup L, Graves-Deal R, Daniel VC, Dempsey PJ, Chinery R, Kirkland SC, DuBois RN, Jetton TL, Morrow JD (1997) Epidermal growth factor receptor activation induces nuclear targeting of cyclooxygenase-2, basolateral release of prostaglandins, and mitogenesis in polarizing colon cancer cells. Proc Natl Acad Sci USA 94: 657–662 - PMC - PubMed
    1. Cowlen MS, Eling TE (1993) Effects of prostaglandins and hydroxyoctadecadienoic acid on epidermal growth factor-dependent DNA synthesis and c-myc proto-oncogene expression in Syrian hamster embryo cells. Biochim Biophys Acta 1174: 234–240 - PubMed

Publication types