doi: 10.1021/jo049703f.
A modular and concise total synthesis of (+/-)-daurichromenic acid and analogues
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- PMID: 15153009
- DOI: 10.1021/jo049703f
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A modular and concise total synthesis of (+/-)-daurichromenic acid and analogues
J Org Chem.
.
Abstract
A modular and concise total synthesis of (+/-)-daurichromenic acid has been accomplished in four steps from ethyl acetoacetate, ethyl crotonate, and trans,trans-farnesal. A series of analogues of this natural product, which has potent anti-HIV activity, were also prepared from ethyl or methyl acetoacetate and a series of readily available alpha,beta-unsaturated esters and aldehydes.
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