Effect of follicle-stimulating hormone on sperm quality and pregnancy rate
- PMID: 15154088
Effect of follicle-stimulating hormone on sperm quality and pregnancy rate
Abstract
Aim: To evaluate the possible links between ultrastructural sperm quality and the clinical pregnancy rate in infertile males treated with FSH before intracytoplasmic sperm injection (ICSI).
Methods: Forty-four infertile males with idiopathic oligo-asthenozoospermia were randomly allocated to the treated (n=24) and non-treated (control, n=20) groups. Semen analysis was carried out by light and transmission electron microscopy (TEM) before and 12 weeks after FSH therapy. ICSI was performed in all couples.
Results: TEM revealed a significant improvement in sperm quality after FSH treatment, particularly in men with their partners achieving clinical pregnancy. The pregnancy rate was 33 % in the treated group and 20 % in the control.
Conclusion: RESULTS highlight a positive role of FSH therapy in infertile males before ICSI, which was correlated with an increased pregnancy rate in treated couples. We believe that improved sperm ultrastructure after FSH therapy could positively influence the quality and early stage of embryo development, thereby increasing the probability of embryo implantation.
Similar articles
-
The effect of follicle-stimulating hormone therapy on sperm quality: an ultrastructural mathematical evaluation.J Androl. 1997 Jul-Aug;18(4):439-47. J Androl. 1997. PMID: 9283958
-
A randomised control trial examining the effect of an antioxidant (Menevit) on pregnancy outcome during IVF-ICSI treatment.Aust N Z J Obstet Gynaecol. 2007 Jun;47(3):216-21. doi: 10.1111/j.1479-828X.2007.00723.x. Aust N Z J Obstet Gynaecol. 2007. PMID: 17550489 Clinical Trial.
-
The beneficial effects of toremifene administration on the hypothalamic-pituitary-testicular axis and sperm parameters in men with idiopathic oligozoospermia.Fertil Steril. 2007 Oct;88(4):847-53. doi: 10.1016/j.fertnstert.2006.12.038. Epub 2007 Apr 6. Fertil Steril. 2007. PMID: 17412336 Clinical Trial.
-
Sperm chromatin structure assay parameters are not related to fertilization rates, embryo quality, and pregnancy rates in in vitro fertilization and intracytoplasmic sperm injection, but might be related to spontaneous abortion rates.Fertil Steril. 2008 Aug;90(2):352-9. doi: 10.1016/j.fertnstert.2007.06.018. Epub 2007 Sep 27. Fertil Steril. 2008. PMID: 17904130 Review.
-
Follicle-stimulating hormone treatment of male infertility.Curr Opin Urol. 2008 Nov;18(6):602-7. doi: 10.1097/MOU.0b013e328313647d. Curr Opin Urol. 2008. PMID: 18832946 Review.
Cited by
-
FSH dosage effect on conventional sperm parameters: a meta-analysis of randomized controlled studies.Asian J Androl. 2020 May-Jun;22(3):309-316. doi: 10.4103/aja.aja_42_19. Asian J Androl. 2020. PMID: 31274479 Free PMC article.
-
Effects of FSH on Sperm DNA Fragmentation: Review of Clinical Studies and Possible Mechanisms of Action.Front Endocrinol (Lausanne). 2018 Dec 11;9:734. doi: 10.3389/fendo.2018.00734. eCollection 2018. Front Endocrinol (Lausanne). 2018. PMID: 30619081 Free PMC article. Review.
-
The use of follicle stimulating hormone (FSH) for the treatment of the infertile man: position statement from the Italian Society of Andrology and Sexual Medicine (SIAMS).J Endocrinol Invest. 2018 Sep;41(9):1107-1122. doi: 10.1007/s40618-018-0843-y. Epub 2018 Feb 1. J Endocrinol Invest. 2018. PMID: 29392544 No abstract available.
-
Empirical medical therapy in idiopathic male infertility: Promise or panacea?Clin Exp Reprod Med. 2014 Sep;41(3):108-14. doi: 10.5653/cerm.2014.41.3.108. Epub 2014 Sep 30. Clin Exp Reprod Med. 2014. PMID: 25309854 Free PMC article. Review.
-
Gonadotrophins for idiopathic male factor subfertility.Cochrane Database Syst Rev. 2013 Aug 23;2013(8):CD005071. doi: 10.1002/14651858.CD005071.pub4. Cochrane Database Syst Rev. 2013. PMID: 23970458 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Medical