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. 2004 Jun;48(6):2280-2.
doi: 10.1128/AAC.48.6.2280-2282.2004.

In vitro activity of OPT-80 against Clostridium difficile

Grit Ackermann  1 , Birgit Löffler, Daniela Adler, Arne C Rodloff
Affiliations

In vitro activity of OPT-80 against Clostridium difficile

Grit Ackermann et al. Antimicrob Agents Chemother. 2004 Jun.

Abstract

Clostridium difficile remains the major cause of nosocomial diarrhea. Reports on impaired susceptibility of C. difficile to metronidazole and vancomycin and frequent relapses of patients after therapy necessitate the search for new substances. With this study, the activity of OPT-80, a new macrocycle, against 207 C. difficile strains and against other obligately anaerobic bacteria was tested. OPT-80 showed high in vitro activity against all C. difficile strains tested.

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