Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2004 Jun;48(6):2280-2.
doi: 10.1128/AAC.48.6.2280-2282.2004.

In vitro activity of OPT-80 against Clostridium difficile

Grit Ackermann  1 , Birgit Löffler, Daniela Adler, Arne C Rodloff
Affiliations

In vitro activity of OPT-80 against Clostridium difficile

Grit Ackermann et al. Antimicrob Agents Chemother. 2004 Jun.

Abstract

Clostridium difficile remains the major cause of nosocomial diarrhea. Reports on impaired susceptibility of C. difficile to metronidazole and vancomycin and frequent relapses of patients after therapy necessitate the search for new substances. With this study, the activity of OPT-80, a new macrocycle, against 207 C. difficile strains and against other obligately anaerobic bacteria was tested. OPT-80 showed high in vitro activity against all C. difficile strains tested.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Brazier, J. S., W. Fawley, J. Freeman, and M. H. Wilcox. 2001. Reduced susceptibility of Clostridium difficile to metronidazole. J. Antimicrob. Chemother. 48:741-742. - PubMed
    1. Deutsches Institut für Normung. 2000. Medizinische Mikrobiologie und Immunologie: Diagnostische Verfahren. Deutsches Institut für Normung, Berlin, Germany.
    1. Fekety, R., L. V. McFarland, C. M. Surawicz, R. N. Greenberg, G. W. Elmer, and M. E. Mulligan. 1997. Recurrent Clostridium difficile diarrhea: characteristics of and risk factors for patients enrolled in a prospective, randomized, double-blinded trial. Clin. Infect. Dis. 24:324-333. - PubMed
    1. Jang, S. S., L. M. Hansen, J. E. Breher, D. A. Riley, K. D. Madigan, Y. J. Tang, J. Silva, Jr., and D. C. Hirsh. 1997. Antimicrobial susceptibilities of equine isolates of Clostridium difficile and molecular characterization of metronidazole-resistant strains. Clin. Infect. Dis. 25:S266-S267. - PubMed
    1. Kyne, L., M. B. Hamel, R. Polavaram, and C. P. Kelly. 2002. Health care costs and mortality associated with nosocomial diarrhea due to Clostridium difficile. Clin. Infect. Dis. 34:346-353. - PubMed

MeSH terms

LinkOut - more resources