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Comparative Study
. 2004 Jun;48(6):2302-4.
doi: 10.1128/AAC.48.6.2302-2304.2004.

In vitro effects of albendazole sulfoxide and praziquantel against Taenia solium and Taenia crassiceps cysts

Francisca Palomares  1 , Guadalupe Palencia, Rodolfo Pérez, Dinora González-Esquivel, Nelly Castro, Helgi Jung Cook
Affiliations
Comparative Study

In vitro effects of albendazole sulfoxide and praziquantel against Taenia solium and Taenia crassiceps cysts

Francisca Palomares et al. Antimicrob Agents Chemother. 2004 Jun.

Abstract

We investigated the minimum exposure times of prazicuantel (PZQ) and albendazole sulfoxide (ABZSO) required for their activities against Taenia cysts in vitro as well as the 50 and 99% effective concentrations. The results showed that although the effects of both drugs are time and concentration dependent, ABZSO acts much slower and is less potent than PZQ.

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Figures

FIG. 1.
FIG. 1.
(A) T. solium cysts: control cysts (left) and dead cysts after treatment with PZQ (right). Note the loss of cystic fluid and that only the scolex is visible after the drug treatment. (B) T. crassiceps cysts: control live cysts (left) and cysts after treatment with the drugs (right). Note the size reduction and the loss of cystic fluid in the parasites.
FIG. 2.
FIG. 2.
In vitro efficacies of PZQ and ABZSO. Each point represents the mean ± standard deviation percentage of dead cysts from three different experiments. □, PZQ against T. solium cysts at 6 h; •, PZQ against T. crassiceps cysts at 4 h; ▵, PZQ against T. crassiceps cysts at 11 days; ▾, ABZSO against T. crassiceps at 11 days.
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