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. 1992 Jul;4(4):281-6.
doi: 10.1016/1043-4666(92)90068-3.

Biological effects of recombinant vaccinia virus-expressed interleukin 4

M E Andrew  1 , B E Coupar
Affiliations

Biological effects of recombinant vaccinia virus-expressed interleukin 4

M E Andrew et al. Cytokine. 1992 Jul.

Erratum in

  • Cytokine 1993 Jan;5(1):89

Abstract

Recombinant vaccinia viruses expressing murine interleukin 4 (IL-4), either alone or together with interleukin 2 (IL-2) or gamma interferon (gamma-IFN), were constructed. Unlike IL-2, IL-4 expressing viruses were not cleared from immunodeficient mice and the mice died. As they died more rapidly than immunodeficient mice inoculated with a control virus, it appeared that IL-4 contributed to their death and the IL-4 mediated toxicity was confirmed in normal immunocompetent mice. The toxicity was reversed by co-expression of either IL-2 or gamma-IFN, probably due to virus clearance and therefore lower levels of circulating IL-4. Vaccinia virus-expressed IL-4 did not increase antibody or natural killer cell levels and caused a slight decrease in cytotoxic T lymphocyte levels.

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