Selective dopamine filter of glutamate striatal afferents
- PMID: 15157413
- DOI: 10.1016/j.neuron.2004.05.008
Selective dopamine filter of glutamate striatal afferents
Abstract
Corticostriatal glutamate afferents and mesostriatal dopamine afferents commonly converge onto the same postsynaptic spines of medium projection neurons. The consequent synaptic triad provides an ideal configuration for dopamine modulation of glutamatergic transmission. In this issue of Neuron, Bamford et al. report that dopamine inhibits glutamate release in a selective manner by activating presynaptic D2 receptors.
Comment on
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Heterosynaptic dopamine neurotransmission selects sets of corticostriatal terminals.Neuron. 2004 May 27;42(4):653-63. doi: 10.1016/s0896-6273(04)00265-x. Neuron. 2004. PMID: 15157425
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