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. 2004 Jun 18;319(1):169-77.
doi: 10.1016/j.bbrc.2004.04.162.

TcZFP1: a CCCH zinc finger protein of Trypanosoma cruzi that binds poly-C oligoribonucleotides in vitro

Patrícia A Mörking  1 , Bruno M Dallagiovanna, Leonardo Foti, Beatriz Garat, Gisele F A Picchi, Adriana C S Umaki, Christian M Probst, Marco A Krieger, Samuel Goldenberg, Stenio P Fragoso
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TcZFP1: a CCCH zinc finger protein of Trypanosoma cruzi that binds poly-C oligoribonucleotides in vitro

Patrícia A Mörking et al. Biochem Biophys Res Commun. .

Abstract

We have identified two zinc finger proteins of Trypanosoma cruzi, the protozoan parasite that causes Chagas disease in humans. These proteins, named tcZFP1 and tcZFP2, share the unusual zinc finger motif (CCCH) found in a diverse range of RNA-binding proteins involved in various aspects of the control of cell homeostasis and differentiation. We report here the functional expression of a recombinant tcZFP1, and the relative affinity and stability of the specific complexes formed between the protein and synthetic oligoribonucleotides containing C-rich sequences.

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