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Review
. 2004 Apr;81(2):223-41.
doi: 10.1016/j.physbeh.2004.02.014.

Leptin signaling

Rexford S Ahima  1 , Suzette Y Osei
Affiliations
Review

Leptin signaling

Rexford S Ahima et al. Physiol Behav. 2004 Apr.

Abstract

The discovery of leptin was a major breakthrough in our understanding of the role of adipose tissue as a storage and secretory organ. Leptin was initially thought to act mainly to prevent obesity; however, studies have demonstrated profound effects of leptin in the response to fasting, regulation of neuroendocrine and immune systems, hematopoiesis, bone and brain development. This review will focus on the signaling pathways which mediate these diverse effects of leptin in the brain and other physiologic systems.

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