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Clinical Trial
. 2004 May 25;62(10):1869-71.
doi: 10.1212/01.wnl.0000125323.15458.3f.

Cholesterol and APOE genotype interact to influence Alzheimer disease progression

R M Evans  1 , S Hui, A Perkins, D K Lahiri, J Poirier, M R Farlow
Affiliations
Clinical Trial

Cholesterol and APOE genotype interact to influence Alzheimer disease progression

R M Evans et al. Neurology. .

Abstract

In this retrospective analysis of 443 Alzheimer disease (AD) patients from a 30-week tacrine trial, change in Alzheimer's Disease Assessment Scale score from baseline to final value was significantly associated with a total serum cholesterol/APOE genotype interaction. Disease progression in the no-APOE epsilon4 allele/high-cholesterol subgroup was greater than in the normal-cholesterol subgroups with or without epsilon4. Cholesterol levels and APOE genotype may interact to affect AD progression. The results are consistent with preclinical data on cholesterol's effects in AD.

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