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Review
. 2004 Jun;21(3):321-52.
doi: 10.1039/b305068h. Epub 2004 May 3.

Enzymatic catalysis of the Diels-Alder reaction in the biosynthesis of natural products

Hideaki Oikawa  1 , Tetsuo Tokiwano
Affiliations
Review

Enzymatic catalysis of the Diels-Alder reaction in the biosynthesis of natural products

Hideaki Oikawa et al. Nat Prod Rep. 2004 Jun.

Abstract

Recent studies on enzymes catalyzing the Diels- Alder reaction. often named "Diels-Alderases", clearlydemonstrated the involvement of this synthetically useful reaction in the biosynthesis of natural products.This review covers natural Diels-Alder type cycloadducts. synthetic efforts on the chemical feasibility ofthe biosynthctic Diels - Alder reaction and a brief history of studies on Diels-Alderases. In addition,reaction mechanisms of artificial and natural Diels--Alderases are discussed.

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