[Risk factors and risk indicators of destructive periodontitis. II. Genetic risk factors (literature review)]

Abstract

After the latest advances in genetic research and basic genetic terminology having been briefly discussed in the second part of the paper, the chromosomal, monogenic as well as polygenic inherited disorders affecting normal PMN leukocyte functions are overviewed. From Down's syndrome to the Papillon-LeFevre syndrome, the different leukocyte adherence deficiencies and also certain inherited metabolic bone diseases, like hypophosphatasia are discussed. Than the recent advances in the research of the role of genetic polymorphisms of lymphokines and certain white blood cell's Fc receptor polymorphism in the development and progression of periodontitis are discussed in details. Finally the role of the ethnic modifying factors in the aetiology of destructive periodontal disease are discussed.