Pharmacokinetics of ethanol in plasma and whole blood: estimation of total body water by the dilution principle

Abstract

The pharmacokinetics of ethanol in plasma and whole blood have been investigated and the results used to estimate the volume of total body water (TBW) by means of the dilution principle. Fifteen men (mean age 62 y) were given 0.6 g ethanol/kg body weight as an intravenous infusion over 1 h. The peak concentration of ethanol in plasma was 120 mg.dl-1 compared to 108 mg.dl-1 for whole blood. The disappearance rate of ethanol from plasma was 18.6 mg.dl-1.h-1 compared to 17.0 mg.dl-1.h-1 for the whole blood concentration-time data. The apparent volume of distribution of ethanol (Vz) was 0.54 l.kg-1 according to plasma kinetics compared to 0.59 l.kg-1 for the kinetics derived from whole blood. The mean area under the curve (AUC) was 294 mg.dl-1 x h for plasma kinetics compared to 266 mg.dl-1 x h for whole blood. The TBW was 40.9 l or 50.9% of body weight for the plasma concentration-time data. This agreed well with the 40.3 l or 50.1% of body weight obtained using whole blood.