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. 2004 Feb;126(1):104-10.
doi: 10.1115/1.1645529.

Mechanical properties of a reversible, DNA-crosslinked polyacrylamide hydrogel

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Mechanical properties of a reversible, DNA-crosslinked polyacrylamide hydrogel

David C Lin et al. J Biomech Eng. 2004 Feb.

Abstract

Mechanical properties of a polyacrylamide gel with reversible DNA crosslinks are presented. In this system, three DNA strands replace traditional chemical crosslinkers. In contrast to thermoset chemically crosslinked polyacrylamide, the new hydrogel is thermoreversible; crosslink dissociation without the addition of heat is also feasible by introducing a specific removal DNA strand. This hydrogel is characterized by a critical crosslink concentration at which gelation occurs. Below the critical point, a characteristic temperature exists at which a transition in viscosity is observed. Both temperature-dependent viscosity and elastic modulus of the material are functions of crosslink density.

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