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Comment
. 2004 Jun 1:4:14.
doi: 10.1186/1471-2148-4-14.

Evolutionary rate depends on number of protein-protein interactions independently of gene expression level: response

Jesse D Bloom  1 , Christoph Adami
Affiliations
Comment

Evolutionary rate depends on number of protein-protein interactions independently of gene expression level: response

Jesse D Bloom et al. BMC Evol Biol. .

Abstract

A response to Fraser HB, Hirsh AE: Evolutionary rate depends on number of protein-protein interactions independently of gene expression level. BMC Evol Biol 2004, 4:13

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References

    1. Fraser HB, Hirsh AE, Steinmetz LM, Scharfe C, Feldman MW. Evolutionary rate in the protein interaction network. Science. 2002;296:750–752. doi: 10.1126/science.1068696. - DOI - PubMed
    1. Jordan IK, Wolf YI, Koonin EV. No simple dependence between protein evolution rate and the number of protein-protein interactions: only the most prolific interactors tend to evolve slowly. BMC Evol Biol. 2003;3:1. doi: 10.1186/1471-2148-3-1. - DOI - PMC - PubMed
    1. Fraser HB, Wall DP, Hirsh AE. A simple dependence between protein evolution rate and the number of protein-protein interactions. BMC Evol Biol. 2003;3:11. doi: 10.1186/1471-2148-3-11. - DOI - PMC - PubMed
    1. Bloom JD, Adami C. Apparent dependence of protein evolutionary rate on the number of interactions is linked to biases in protein-protein interactions data sets. BMC Evol Biol. 2003;3:21. doi: 10.1186/1471-2148-3-21. - DOI - PMC - PubMed
    1. Pal C, Papp B, Hurst LD. Highly expressed genes in yeast evolve slowly. Genetics. 2001;158:927–931. - PMC - PubMed

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