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. 1992;118(8):615-20.
doi: 10.1007/BF01211807.

Prognostic factors in WHO grade 2 transitional-cell bladder cancer (TCC); a novel two-grade classification system for TCC based on mitotic index

P K Lipponen  1 , M J Eskelinen, K Jauhiainen, E Harju, P Terho, H Haapasalo
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Prognostic factors in WHO grade 2 transitional-cell bladder cancer (TCC); a novel two-grade classification system for TCC based on mitotic index

P K Lipponen et al. J Cancer Res Clin Oncol. 1992.

Abstract

A retrospective histological analysis has been carried out on 537 cases of transitional-cell bladder carcinoma, followed-up over a period of 9 years. In the first part of the study WHO grade 2 tumours were analysed and a number of independent factors predictive for survival identified. In a multivariate analysis the T category and M/V index (number of mitotic figures/mm2 neoplastic epithelium) were the most important prognostic factors. In a subsequent analysis of the whole series of 537 cases, overall the M/V index was not as important in predicting survival as the stage of the tumour. However, in superficial tumours (Ta-T1) subsequent analysis showed that the M/V index alone could be used to predict survival.

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References

    1. Aaltomaa S, Lipponen P, Eskelinen M, Kosma V-M, Marin S, Alhava E, Syrjänen K (1991) Prognostic scores combining clinical, histological and morphometric variables in assessment of the disease outcome in female breast cancer. Int J Cancer 49:886–892 - PubMed
    1. Baak JPA, Oort J (1983) Manual of morphometry in diagnostic pathology. Springer, Berlin Heidelberg New York
    1. Bergkvist A, Ljungqvist A, Moberger G (1965) Classification of bladder tumours based on cellular pattern. Preliminary report of a clinical-pathological study of 300 cases with a minimum follow-up of eight years. Acta Chir Scand 130:371–378 - PubMed
    1. Blomjous CEM, Schipper NW, Baak JPA, de Voogt HJ, Meijer CJLM (1989a) Comparison of quantitative and classic prognosticators in urinary bladder carcinoma. Virchows Arch [A] 415:421–428 - PubMed
    1. Blomjous CEM, Schipper NW, Baak JPA, Vos W, De Voogt HJ, Meijer CJLM (1989b) The value of morphometry and DNA flow cytometry in addition to classic prognosticators in superficial urinary bladder carcinoma. Am J Clin Pathol 91:243–248 - PubMed

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