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. 2004 Jun 4;14(5):667-73.
doi: 10.1016/j.molcel.2004.05.013.

Removal of promoter nucleosomes by disassembly rather than sliding in vivo

Hinrich Boeger  1 , Joachim Griesenbeck, J Seth Strattan, Roger D Kornberg
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Free article

Removal of promoter nucleosomes by disassembly rather than sliding in vivo

Hinrich Boeger et al. Mol Cell. .
Free article

Abstract

Previous work demonstrated the removal of nucleosomes from the PHO5 promoter upon transcriptional activation in yeast. Removal could occur by nucleosome disassembly or by sliding of nucleosomes away from the promoter. We have now activated the PHO5 promoter on chromatin circles following excision from the chromosomal locus. Whereas sliding would conserve the number of nucleosomes on the circle, we found that the number was diminished, demonstrating chromatin remodeling by nucleosome disassembly.

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