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Comparative Study
. 2004 Aug;29(7):825-9.
doi: 10.1016/S0306-4530(03)00146-X.

Pulsatile luteinizing hormone disruption in depression

Patricia Grambsch  1 , Elizabeth A Young, William H Meller
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Free article
Comparative Study

Pulsatile luteinizing hormone disruption in depression

Patricia Grambsch et al. Psychoneuroendocrinology. 2004 Aug.
Free article

Abstract

Two independent groups recently published data comparing pulsatile luteinizing hormone (LH) release between depressed and control women. Despite similar populations and LH sampling frequency, they reached different conclusions: Meller et al. [Am. J. Psych. 154 (1997) 1454] found disruption of normal LH pulsatility in depressed women, whereas Young et al. [Arch. Gen. Psych. 57 (2000) 1157] did not. To resolve this discrepancy, the current study applies a single, well-established statistical method, spectral analysis, to the two data sets and concludes that both depressed populations display significantly altered LH pulsatile release.

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